Infections have been shown to reduce dopamine levels.Dopamine levels can affect “reward”, mood, energy production and movement. In the brain dopamine is produced mostly in the basal ganglia region.(One might call it an anti-anti-psychotic.) At the lower doses used in ME/CFS, though, it enhances dopamine production. In the higher doses used to treat schizophrenia and other disorders Abilify reduces dopamine production.When use correctly it tends to stabilize dopamine levels at more optimum levels. Abilify is a “2nd generation anti-psychotic” that was not used as an anti-psychotic in ME/CFS at all.Abilify is the drug that helped Whitney Dafoe communicate again.Low dose naltrexone, for instance, has very different effects than at the higher doses the drug is mostly known for. It’s both an antidepressant, and not an antidepressant.”įinding that drugs operate very differently at low or high doses does not appear to be that unusual. “Thus, Abilify can be seen, at the same time, as both an antipsychotic, and not an antipsychotic. One psychiatrist explained the Jekyll and Hyde nature of Abilify’s dopamine stabilizing role like this: in high doses, it inhibits dopamine production and stimulates it at lower doses. At the higher levels prescribed in schizophrenia and other diseases, it inhibits them i.e. When given in the doses used in ME/CFS, it should actually make schizophrenia and similar diseases much worse.Ībilify is a “dopamine system stabilizer” at the low levels it’s used in ME/CFS, it stimulates the D2 class of dopamine receptors ( D2, D3, D4). In fact, it operates so differently in ME/CFS that it could be called an anti-anti-psychotic drug. If ME/CFS has never been associated with psychosis, why would an anti-psychotic help? Because when Abilify is used the way it is in ME/CFS, it does not have anti-psychotic properties. Abilify is a “dopamine stabilizer”: at high doses it will inhibit dopamine production at low doses it will increase it.
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